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Abivax: ABX464抑制SARS-CoV-2(2019新冠肺炎)在重组人呼吸道上皮模型中的复制

来源:北京消费网| 2020/5/19 18:26:56|

ABX464是唯一对COVID-19治疗有潜在三重作用的候选药物:抗病毒、抗炎和组织修复

    ·ABX464TONGGUORTqPCRPINGGU,KEYIZHISARS-CoV-2(COVID-19)DETIWAIBINGDUFUZHI

长春配资开户    ·TONGSHI,AbivaxHUOANSMHECPPPIZHUN,[1]ZAI2b/3QINARU1,034LIHUANZHEDESUIJImiR-AGELINCHUANGSHIYANZHONG,CESHIABX464DELIAOXIAOYIZUOWEIJUQIANJINGDECOVID-19ZHILIAOHOUXUANYAOWU

    ·COVID-19HUANZHESIYUYOUBINGDUFUZHIYINQIDEFEIBUYANZHENGHUOZHANGQIXIANWEIHUADAOZHIDEJIXINGHUXISHUAIJIE

    ·ABX464SHIWEIYIYIZHONGJUYOUSANZHONGHUOXINGDEHOUXUANYAOWU,ZAITIWAIKEYIZHISARS-CoV-2DEFUZHI,ZAIKUIYANGXINGJIECHANGYANHUANZHEZHONGKEJIANQINGYANZHENGBINGCUJINZUZHIXIUFU

长春配资开户    ·ABX464JIANGFUHEMEIGUOGUOLIWEISHENGYANJIUYUAN/GUOMINYUCHUANRANZHENGYANJIUSUO(NIH / NIAID)2019XINGUANFEIYANXINYAODEZHANLVEZHONGDIAN:KANGBINGDU、KANGYAN、ZUZHIXIUFU、KOUFU、FANGBIANDEMEIRIYICIJIYAO

    FAGUOBALI – EQS Newswire - 2020NIAN5YUE19RI - LINCHUANGJIEDUANSHENGWUJISHUGONGSI(BALIFANOUZHENGQUANJIAOYISUOJIAOYIDAIMA:FR0012333284-ABVX)SHIYIJIALINCHUANGJIEDUANSHENGWUJISHUGONGSI,LIYONGMIANYIXITONGKAIFAZHENDUIYANXINGJIBING、BINGDUXINGJIBINGHEAIZHENGDEXINXINGLIAOFA,QIJINTIANXUANBUJINGKUASHANGPIDIANZUHERTqPCRPINGGU,ABX464KEZAITIWAIZHONGJIANDERENLEIHUXIDAOSHANGPIMOXINGZHONGYIZHISARS-CoV-2DEFUZHI。ZAIYANZHONGDEYANZHENGXINGJIBING、KUIYANGXINGJIECHANGYANZHONG,ABX464YIBEIZHENGMINGSHIYOUXIAODEHOUXUANYAOWU。 ABX464DUImiR-124DETEYIXINGSHANGDIAOKEYIJIESHIGAIHOUXUANYAOWUZAIYIZHIBINGDUFUZHI、XIADIAOHUIYOUDAOYANZHENGDEXIBAOYINZIHECUJINZUZHIXIUFUFANGMIANDESANZHONGZUOYONG。

    AbivaxJINTIANBAODAODETUPOXINGKEXUESHUJUSHIABX464CHENGWEI2019XINGUANFEIYANHUANZHEDUTEDEQIANZAIZHILIAOFANGFA。MUQIANDEDALIUXINGJIBINGHEHUANZHEDUIBINGDUFUZHIDEGUODUYANZHENGFANYINGSHIDAOZHIJIXINGHUXIJIONGPOZONGHEZHENG(ARDS)HE2019XINGUANFEIYANHUANZHESIWANGDEZHUYAOYUANYIN。ABX464FANGBIANDEKOUFUJIYAOHEQIANZAIDEDUTESANZHONGZUOYONGMOSHI,JIANGZUOWEIYIZHONGQIANZAIDEXINLIAOFAZAIOUZHOULINCHUANGSHIYANZHONGJINXINGJINJISHIYAN,YIBIAN:

    ·预防和减少炎症长春配资开户。疗效已显示在另一种严重的炎症性疾病——溃疡性结肠炎上。事实上,ABX464已经被证明可促进miR-124的表现,“自然抑制”炎症。miR-124能抑制参与2019新冠肺炎细胞因子风暴的多种化学和细胞因子,包括TNFα、IL-1β、G-CSF、IL-6、MCP-1和IL-17

    ·减少病毒复制长春配资开户。通过RNA质量控制和miR-124对dynamin 2的抑制作用来实现,该蛋白是病毒复制所必需的关键成分。

    ·促进组织修复,并减少肺部纤维化。

长春配资开户    ABX464TONGGUOYUMAOZIJIEHEDANBAIFUHEWU(CBC)JIEHE,KEYIJIANJIEFEIBIANMARNA—— LncRNA 205,CONGERCHANSHENGmiR-124。miR-124SHIYIZHONGYOUXIAODEXIAOYANXINGXIAOFENZIHETANGHESUAN,KEFANGZHISHANGSHUDUOZHONGHUAXUEHEXIBAOYINZIDEFANYI。 CIWAI,SARS-CoV-2DEFUZHIXUYAOdynamin 2,ZHEISHIYIZHONGGTPMEI,FUZEBINGDUDENANGPAOQIEKAIHEXIBAOCHUANTOU。DONGLIDANBAI2SHImiR-124DEMUBIAOJIYIN,BINGTONGGUOmiR-124CUJINBIAODAERYIZHIBIAODA。

长春配资开户    KANGBINGDUSHIYANSHIZAIFAGUOLIANGDIYIDAXUE(Claude-Bernard-Lyon-1 University)DECHUANRANBINGXUE黄金配资 YANJIUZHONGXINVirPathSHIYANSHIJINXINGDE。

    法国里昂黄金配资 感染生物学研究中心的VirPath联合主任Manuel Rosa Calatrava博士说:“虽然体外实验结果不能预测患者的临床疗效,但除了已知的抗炎特性外,我们实验室获得的ABX464对SARS-CoV-2的抗病毒效果非常令人振奋。ABX464的抗病毒作用和对组织完整性的保护是显著的,因为它们是基于体外重建的人肺上皮生理模型,而不是基于更基本的猴肾Vero E6细胞模型”。

    Abivax董事长兼Truffle Capital首席执行官Philippe Pouletty医学博士说长春配资开户:“当我们为ABX464的抗SARS-CoV-2效应申请专利时,基于我们对其作用机制和冠状病毒生理病理学的研究,我们对在如此严格的人肺上皮模型中显示抗病毒作用的能力非常谨慎。我们要感谢VirPath团队能够迅速而严格地完成这件事。”

    Abivax首席执行官Hartmut Ehrlich博士补充道:“我们证实ABX464抗SARS-CoV-2的抗病毒作用,进一步加强了启动miR-AGE临床研究的理论基础,使ABX464成为有望进行临床研究的候选药物。随着ANSM(法国监管机构)和人员保护委员会最近批准了miR-AGE临床试验,我们将很快开始招募患者,以了解ABX464的这三种活性是否可以转化为对2019新冠肺炎确诊患者的临床疗效。”

长春配资开户    ABX464QIANZAIDESANZHONGZUOYONGFEICHANGYOUQIANJING,TASHIDANGJINSHIJIESHANGWEIYIXIANSHICHUZHEIZHONGHUBUXINGDEHOUXUANYAOWU。CIWAI,BIANJIEDEABX464MEIRIKOUFUJIYAOKEZAIYANZHONGBINGFAZHENGFASHENGZHIQIANRANGHUANZHEZAIYUANNEIHUOYUANWAIJIZAOJIESHOUZHILIAO,QIANZAIDIYINGXIANGBINGDUFUZHI、XIBAOYINZICHANSHENG、FEIZUZHIXIUFU。

    关于Abivax

    AbivaxSHIYIJIALINCHUANGJIEDUANDESHENGWUJISHUGONGSI,TAZHILIYUDIAOJIERENTIDEZIRANMIANYIJIZHILAIZHILIAOZISHENMIANYIXINGJIBING、BINGDUGANRANHEAIZHENGHUANZHE。AbivaxZAIOUZHOUQIHUOJIAOYISUOBJISHICHANGGUAPAISHANGSHI(ISIN: FR0012333284 - Mnémo: ABVX)。AbivaxZONGBUWEIYUBALIHEMENGBILIAI,YOULIANGZHONGHOUXUANYAOWUCHUYULINCHUANGKAIFAJIEDUAN:ZHILIAOYANZHONGYANZHENGJIBINGDEABX464HEZHILIAOGANXIBAOAIDEABX196。

长春配资开户    GUANYUGAIGONGSIDEGENGDUO股票配资 QINGCHAYUE。ZAITwitter @ABIVAXSHANGGUANZHUWOMEN。

    关于Truffle Capital

长春配资开户    Truffle CapitalCHUANGBANYU2001NIAN,SHIYIJIADULIDEOUZHOUFENGXIANTOUZIGONGSI,ZHUANZHUYUSHENGMINGKEXUE(SHENGWUJISHUHEYILIAOJISHU)YIJIJINRONGJISHUHEBAOXIANJISHULINGYUDETUPOXINGJISHU。Truffle CapitalDESHIMINGSHIZHICHINENGGOUCHENGWEIWEILAILINGDAOZHEDENIANQINGCHUANGXINXINGGONGSIDECHUANGBANHEFAZHAN。GENGDUO股票配资 : - Twitter: @trufflecapital

长春配资开户    [1] QINGYUEDUYOUGUANCI配资开户 DE配资开户 GAO:“

长春配资开户    [2] CHAOGUO1000PIANKEXUEWENZHANGJIESHILEmiR-124DUIYANZHENGDEZUOYONGJIZHI。ZAIYIXIANG2aQIANWEIJIDUIZHAOLINCHUANGSHIYANZHONG,ZHENDUIDUILEIGUCHUNHESHENGWUYAOWUNAIYAODEZHONGZHONGDUKUIYANGXINGJIECHANGYANHUANZHE,ABX464NENGXIANZHUJIANGDIYANZHENG,BINGYOUDAOLINCHUANG、SHENGWUHENEIJINGHUANJIE。MUQIANABX464ZHENGZAI17GEGUOJIADEKUIYANGXINGJIECHANGYAN2bQILINCHUANGSHIYANZHONGJIESHOUPINGGU。TASHILINCHUANGFAZHANZHONGWEIYIYIZHONGTEYIXINGSHANGDIAOmiR-124DEHOUXUANYAOWU,miR-124SHIYIZHONGXIADIAOXIBAOYINZIXINHAOHEYANZHENG、CUJINZUZHIXIUFUHEYIZHISARS-CoV-2FUZHIDESHENGLIXINGXIAOFENZIHETANGHESUAN。YUSARS-CoV-2YOUDAODEXIBAOYINZIFENGBAOYOUGUANDETNFα、IL-1β、G-CSF、IL-6、MCP-1HEIL-17JUNBEImiR-124YIZHI。